ABSTRACT
Because of the relevance of an early and accurate diagnosis for prognosis, management,
and participation of patients in research, the classical clinical features-features
that should raise suspicion of progressive supranuclear palsy (PSP) and those that
should make the diagnosis of PSP unlikely-are discussed in this article. The accuracy
of currently used clinical diagnostic criteria and the role of laboratory investigations
in the diagnosis of PSP are reviewed. New terminology for the clinical diagnostic
criteria for PSP is proposed. The main neuropathologic and neurochemical features
supporting current main symptomatic and hypothesized experimental biologic therapies
are suggested.
KEYWORD
Progressive supranuclear palsy - diagnosis - treatment - atypical Parkinsonian disorders
